Journal: Frontiers in Cellular Neuroscience

Article Title: Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory

doi: 10.3389/fncel.2026.1833859

Figure Lengend Snippet: Contextual fear conditioning performance. (A) Schematic diagram of the CFC paradigm showing the single-shock training session and the memory test 24 h later. (B) Learning curve across training days (D1–D3). Saline- and 25 mg/kg KA treated mice showed a progressive increase in freezing behavior, whereas 5 mg/kg KA-administered mice showed a learning delay as they displayed a similar % in freezing time as on Day 1 (* p < 0.05 vs. Sal and 25 mg/kg KA at D2; gray box indicates this time point). (C) Freezing behavior on D2. Animals from the 5 mg/kg KA group exhibited significantly lower freezing compared to the saline and 25 mg/kg groups (* p < 0.05). (D) Freezing levels during the memory test. No significant differences were observed among groups. Data are expressed as mean ± SEM. n = 16 (Sal), n = 14 (5 mg/kg KA), n = 15 (25 mg/kg KA).

Article Snippet: The test was performed in a mouse conditioning chamber (25 cm × 25 cm × 20 cm) (San Diego Instruments, San Diego, CA, USA) with transparent acrylic walls and a metal rod floor.

Techniques: Saline

Journal: bioRxiv

Article Title: TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

doi: 10.1101/2025.10.20.683438

Figure Lengend Snippet: (A) Diagram of the weight drop device used to induce multiple closed-skull impacts with a 50g weight dropped from a 15cm height within a single surgical session. Location of impact site (red circle) is shown on the right. Created with biorender.com. (B) Illustration depicting the location of the impact site (red lightning bolt and oval). Several brain regions of interest are highlighted as follows: cortex (Ctx), amygdala (Amg), and hypothalamus (Hypo) on both ipsilateral and contralateral sides of the brain. Created with biorender.com. (C) Neurological severity score (NSS) plotted as a function of time post-surgery and cohort (see key). Statistically significant comparisons shown on the graph include Q331K TBI versus Q331K sham at 2h (****p=2.98e -6 ), 24h (***p=0.00058) and 48h (***p=0.00018) post-surgery, WT TBI versus WT sham at 2h post-surgery ( ### p=0.00070) and Q331K TBI versus WT TBI at 2h ( ΔΔΔ p=0.00026), 24h ( ΔΔΔ p=0.00022) and 48h ( ΔΔ p=0.0058) post-surgery. Additional significant comparisons include Q331K TBI versus WT sham at 2h (p=7.0e -10 ), 24h (p=2.54e -6 ) and 48h (p=0.00014) post-surgery. (D-G) Mice were randomly assigned to Group 1 (sham) or 2 (TBI). Results of the cued and contextual fear conditioning (CCFC) test. (E) The Q331K-2 cohort exhibited altered freezing behavior during conditioning compared to Q331K-1 (*p=0.028) and WT-2 (*p=0.017). (F) Both Q331K cohorts exhibited attenuated cue-induced freezing relative to WT animals (*p=0.012 for WT-2 vs. Q331K-1; **p=0.009 for WT-2 vs. Q331K-2) pre-surgery. WT animals exhibited attenuated cue-induced 5-months after sham ( # p=0.048) and TBI ( ### p<0.001) surgeries.

Article Snippet: Mice were placed in a Ugo Basile Fear Conditioning Chamber (Noldus, BOM-XUGO-F101) made of optical transparent plastic 26 cm long, 26 cm wide and 38 cm tall.

Techniques:

Journal: eLife

Article Title: Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

doi: 10.7554/eLife.87644

Figure Lengend Snippet:

Article Snippet: Other , Med Associates operant chamber , Med Associates , Cat# MED-307W-D1 , .

Techniques: Virus, Plasmid Preparation, Software